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ALTORIS provides consulting services in
computer assisted drug design. Our consulting services are flexible, from punctual projects
to strategic guidance in the drug design arena. Our professional network has a comprehensive
view of the full drug discovery cycle that allows our customers to have a partner that not
only understands the tools but also is familiar with the needs of a drug discovery program.
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Pharmacophore identification, QSAR, Docking, Virtual Screening
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Screening Library design: focused, fragment or general purpose.
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In-silico toxicology and ADME prediction
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Scientific software application development
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Infrastructure development: Software and hardware selection
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Management Consulting: recruiting, restructuring
A Few Sample Case Studies:
Developed a series of
homology models
for a panel of related enzymes to identify pan selective
inhibitors. In collaboration with medicinal chemists, docked
candidate structures and selected most promising scaffolds for
follow-up.
Aided company in the selection of software to establish a molecular
modeling facility. From delineating requirements to participation in negotiations
with vendors, to the training of staff we participated in the entire facility build
up process.
Carried out virtual screening for a kinase target
with the ultimate purpose of improving the activity and pharmacokinetic profile of leads
identified by HTS.
Trained personnel in the techniques for lead hopping
when no structural information on the target was available.
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